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CBD Oil and Pain Relief: Is It All in the Mind?

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CBD Oil and Pain: Physiology, Placebo, or Both?

Source: Kindel Media / Pexels

Chronic pain seems to be a serious ailment for many people and especially for an increasing number of young people. A new report found that the proportion of people in England aged 16 to 34 who experienced severe chronic pain increased dramatically between 2011 and 2017. They define this as pain that is so acute that it lasts for over 12 weeks despite treatment or medication.

Long-term dependence on opioid drugs is recognized as an undesirable way of treating chronic stress over the long term. In fact, promoting physical activity and fighting obesity could address some factors that could be responsible for this widespread experience of chronic pain.

CBD Oil and Pain: Placebo Effect?

But is there any other treatment that could help while we encourage people to make these behavior changes? What is the evidence that cannabidiol (CBD) oil can help with chronic pain? And if this works, how much of it is due to physiological mechanisms attributed to CBD oil versus a placebo effect? This is exactly what a recently published study looked at.

As the stigma surrounding cannabis use slowly erodes and cannabis use legislation is liberalized, people have largely reported that cannabis provides similar pain relief when compared to other drugs. This finding extends to forms of cannabinoids such as CBD oil, which appear to have moderate to large effects on self-reported pain. Placebo treatments also seem to have a small to moderate effect on self-reported pain. We know that perception can greatly influence this pain. It has been difficult to unravel how much of the analgesic effects of cannabinoids are due to poisoning, a placebo effect, and / or a direct physiological effect. A recent experimental balanced placebo pain study attempted to understand the independent and / or combined effects of expected or actual use of CBD oil on pain reactivity.

In the study, the researchers randomly assigned participants to four experimental conditions in which they received instructions along with the test product: control (inactive drug indicated and administered); Expectation (actively told, indicated inactive); Drug (given inactive, active CBD oil); and expectation plus medication (told and given actively). After an absorption time of 30 minutes, two thermodes that could apply 20 to 52 ° C (quantifiable sensory stimuli) were applied and used to evaluate static and dynamic pain measures in different ways.

The results showed clear effects in only two measurements. Discomfort, a static measure of pain, was reduced equally by both CBD alone and the expectation of getting CBD: both the placebo effect and CBD seemed to reduce this aspect of pain, but the combination of CBD and expectation did not add anything Use. Continuous pain modulation, a dynamic pain metric, was also influenced by expectation and CBD alone. Oddly enough, their combination didn’t seem to have any additional effect either.

Direct physiological and placebo effects can co-exist

So what can we do with these results? The short story is that psychological expectations and pharmacological effects are driving CBD-induced pain relief. However, we have to exercise some caution here. Pain itself is a complex phenomenon that can be influenced by many variables, some of which are not fully understood – this is even more true of chronic pain.

This study was limited to acute treatments, heat-related pain, and participants were also advocates of CBD use. It is not clear whether this placebo effect of CBD would work beyond the acute treatment and / or on non-heat-induced pain stimuli. There is evidence that CBD has antioxidant and anti-inflammatory properties that may be directly or indirectly related to chronic pain and related conditions such as rheumatoid arthritis, but further studies of long-term CBD exposure would be needed to paint a clearer picture.

A broader paper makes one thing clear: even if participants are told the power of the placebo effect, they can still experience the placebo effect. And with hemp or CBD oil, this can occur at the same time as direct physiological effects. However, they don’t seem to have an additive effect. Why this is exactly the case remains a mystery that needs to be solved.

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Study Suggests Hemp Extract Is An Effective Weight-Loss Aid

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A proprietary hemp extract shows promise as a supplement for promoting weight loss, according to a study funded by a grant from the National Institutes of Health. Data from the double-blind, placebo-controlled study showed that all 100 participants who took Nitro-V hemp extract daily lost weight and lost up to 22 pounds over 90 days. The minimum weight loss for those taking the supplement was 5 pounds, while 64% of participants in the placebo group either gained weight or saw no change.

The study participants who took the hemp extract, which is high in cannabidiol (CBD), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), and other cannabinoids, also showed improvements in other metabolic health metrics and important wellness indicators without changing their diet and exercise habits to change. Participants who took Nitro-V saw their body mass index (BMI) decrease an average of three points and lost an average of 2.4 inches from their waist measurements. On average, the study participants in the placebo group gained weight and saw that their BMI remained the same.

Cannabis (hemp) extract.

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Almost 75% of Americans are overweight

According to data from the CDC, more than 73% of adults 20 years or older in the United States are overweight or obese. The health risks associated with obesity can be serious and include heart disease, diabetes, and high blood pressure. Additional CDC data shows that between 2013 and 2016, more than 49% of American adults reported trying to lose weight in the past 12 months.

“Those working to lose weight and improve their overall health are looking for every benefit they can find to help them stick to their exercise and nutrition plans,” said Arthur Jaffee, CEO of Nitro-V manufacturer ECS Brands , in a press release. “Given the results of these studies, we believe that Nitro-V could be the tool to help many achieve their weight loss potential and feel better.”

To conduct the clinical study, which had not yet been published in a peer-reviewed journal, the researchers assembled a group of 125 subjects to participate in the research. A total of 100 participants received either one or two 50 mg servings of Nitro-V daily, the remaining 25 participants received a placebo. Study participants were not told that they were participating in a weight loss study and that they had not changed their diet or exercise habits.

At the beginning and end of the 90-day study period, participants visited the Mayo Clinic campus in Scottsdale, Arizona and completed standardized surveys on health determinants such as diet, appetite, anxiety, and pain. The researchers also monitored the subjects’ weight, BMI, waist circumference, and vital signs, and performed full blood tests to measure blood sugar, cholesterol, and organ health, as well as other diagnostic tests. A statistician analyzed the data collected during the study to identify trends and evaluate the importance of the results. The research was funded by a small business owned by the National Institutes of Health and conducted by a contract researcher with 20 years of experience in product safety studies.

Each softgel microcapsule serving of Nitro-V contains 50 mg of hemp extract with a combination of cannabinoids such as CBD, THCV and CBDV in an organic hemp seed oil base. The solvent-free hemp extract contains the full cannabinoid profile of the source plant, including less than 0.1% THC. Further processing increases the THCV and CBDV levels in the supplement.

The “thin cannabinoid”

Cannabinoids from cannabis, including hemp, act on the body’s endocannabinoid system, which helps maintain physiological, cognitive, and emotional stability. Research has shown that THCV can act as an effective appetite suppressant, which has earned it the nickname “thin cannabinoid”. Other studies have shown that THCV can also help regulate blood sugar levels. THCV also has anti-inflammatory and antispasmodic properties.

Nitro-V hemp extract softgels from ECS Brands.

Photo courtesy of ECS Brands

Jaffee notes that recent research has shown that CBD and THCV can affect lipid and glucose metabolism in animals, both important factors in maintaining a healthy weight. The study also found that CBD had several positive effects on hyperglycemia, largely due to its anti-inflammatory and antioxidant properties. Further evidence from animal studies shows that CBD modulates the cardiovascular response to stress, which plays a role in weight gain and loss. However, the link between CBDV and weight loss is “less direct,” he says.

“Research shows that CBDV is a powerful anti-inflammatory agent that can play a role in both appetite and weight,” Jaffee wrote in an email. “Reduced inflammation in the body helps optimize the performance of the metabolic organs, and fat cells themselves are metabolic organs. Inflamed fat cells do not work properly and can contribute to unhealthy weight gain. “

The Nitro-V study also showed several other changes in the health and well-being of the participants, including many with the potential to affect weight loss. Participants who used the supplement in the study showed a 61% reduction in hunger and had fewer food cravings. In addition, all 37 study participants who took Nitro-V and were classified as prediabetic had their blood sugar levels returned to normal by the end of the 90-day study. The subjects also reported less difficulty resisting food cravings and showed improvements in sleep, happiness, and anxiety. Research also showed that the hemp extract was well tolerated and safe, with blood tests showing that all safety and toxicity levels remained within healthy, normal ranges.

A hemp field in rural Belgium.

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While the study was designed to examine the effects of Nitro-V on weight loss, Jaffee says the data suggests the supplement may have other health and health benefits as well.

“The ultimate goal of the study was to identify the overarching power of the ECS system, and the results indicate effects beyond weight loss and appetite suppression,” he writes. “But as with all cannabinoid and ECS researchers today, we still have many unanswered questions about how interactions between cannabinoids and the ECS lead to health improvements.”

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Could CBD Oil Help with Nausea?

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When it comes to the CBD industry, misinformation is rampant. There are too many brands out there trying to make quick money in a phenomenally fast growing market. With a lot of money at stake, these companies are less concerned about what they can do for their customers and more concerned about their profit margins.

The benefits of CBD are known due to the relentless research of dedicated scientists. However, the actions of certain brands lead the general public to remain skeptical.

My advice is to avoid brands that claim that their CBD oil “treats” everything. Unless the cannabinoid is approved by the FDA for medical treatment, no brand is allowed to make any medical claims. However, there is no question that CBD is a potential life changer for many people, for example against nausea. Let’s find out more.

What is nausea?

It is usually classified as a stomach discomfort that makes you want to throw up. It affects a wide variety of people and can have a variety of causes. Common reasons for nausea are:

  • heartburn
  • GERD
  • An infection or a virus
  • Motion sickness
  • Extreme pain
  • Medication

It’s important to remember that nausea is not a disease in itself. Instead, it’s your body’s response to one of a number of conditions. Although it feels awful, nausea is often necessary for your body to fight off unwanted invaders.

Although there are several anti-nausea drugs on the market, there is evidence that CBD may be effective against nausea.

How could CBD help with nausea?

THC is the most common intoxicating cannabinoid found in marijuana. It’s also available in small quantities in hemp. THC is known to create a high, and it binds to endocannabinoid receptors in the brain and spinal cord.

CBD works on these receptors too, but in a different way. First of all, it doesn’t bind directly to the CB1 and CB2 receptors. This helps explain why it doesn’t induce an intoxicating high. CBD helps the body produce higher levels of endocannabinoids like anandamide.

What does the research say?

Currently, much of the research on CBD for nausea is based on people with cancer. Nausea and vomiting are common side effects of chemotherapy. A study published in 2016 examined how cannabinoids can regulate acute and anticipatory nausea. The researchers found that a combination of THC and CBD could provide some relief to cancer patients undergoing chemotherapy.

The American Cancer Society actually puts cannabinoids on its list of drugs to use to treat nausea and vomiting. It suggests that these compounds may be useful in cases where traditional anti-nausea medications are ineffective.

A 2011 review of animal studies also looked at how cannabinoids can regulate nausea and vomiting. The researchers found that CBD was potentially useful against nausea due to its interaction with serotonin receptors. Serotonin is a hormone that affects our mood, behavior, and wellbeing.

THC is potentially more effective at reducing the effects of nausea. However, it causes a high intoxication and is not legal in over a dozen US states. It’s also not legal in many countries around the world. Although CBD is not strictly legal in America, it is widely used and tolerated. It is also widely used around the world, with many nations specifically saying that it is legal.

What types of CBD should I use for nausea?

You will likely get more benefits from CBD for nausea by trying a full-spectrum product. This is because research suggests that the presence of THC might increase its anti-nausea effects. A full-spectrum CBD product contains dozens of compounds and terpenes. However, in the United States, it cannot contain more than 0.3% THC. In the UK, the maximum THC content is 0.2%.

When you feel sick, it makes sense to avoid anything that could make you feel like you are vomiting. While some people can tolerate edibles or oils, others cannot. CBD capsules are another option. They have no taste and are easy to swallow. You could try vaping CBD for a faster effect, but your stomach may not like it!

It also makes sense to start with a relatively low dose and work your way up. Start with 5-10 mg of CBD and increase it as needed.

Final thoughts on CBD for nausea

According to the research available, there is plenty of evidence that CBD could be effective against nausea. While most of the studies are on cancer patients recovering from chemotherapy, you may find that CBD works for your nausea. There are also many other potential benefits of CBD that are worth exploring.

When trying out CBD for nausea, you need to carefully consider your method of consumption. Buy a moderate amount first to see how you react. If you can handle it, you can buy more and possibly increase the amount you consume.

Image by unbekanntuserpanama from Pixabay

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Biomedican receives approval notification from the U.S. Patent Office on its first patent — Greenway Magazine

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Biomedican has received notification from the U.S. Patent Office that its first patent has been granted and will be issued in the coming months. This is the first patent ever issued using Yarrowia Lipolytica to make cannabinoids.

“This is a very important milestone for Biomedican as it will be the first patent issued using Yarrowia Lipolytica to make cannabinoids. Yarrowia Lipolytica is an oily yeast that naturally produces large amounts of oil. Our variety can produce over 80% of the oils from dry cell mass. The cannabinoid pathway relies on the same precursors that are needed for oil production. Cannabis produces cannabinoids in oil droplets on trichomes. Enzymes that convert CBGA to CBDA, CBCA, and THCA are required for two phases to interact: oil and water. Our yeasts have oil droplets inside, which are natural stores for cannabinoids. Basically, we completely imitate the natural production process of our yeast, ”says CEO Dr. Maxim Michejew, Ph.D.

To the best of our knowledge, many other companies have problems making late-stage enzymes that work in baker’s yeast, E. coli, pitchia pastoris, and microalgae.

Most cannabinoids are known for their antifungal and antibacterial properties. This means that they are toxic to a wide variety of bacteria, yeasts, and fungi. In fact, several publications have shown the toxicity of cannabinoids to cannabis plants as well. Because of this, cannabis produces cannabinoids outside of cells on specialized cells – trichomes.

Yarrowia Lipolytica is famous for its high resistance to toxic compounds. Cannabinoids are not toxic to Yarrowia Lipolytica. In our experiments, the wild type of YL was able to use cannabinoids as a carbon source. Basically, she ate it instead of sugar with no toxic effects. We had to modify our strain to prevent cannabinoid use.

“As a result of this patent and three other patents pending, our varieties of cannabinoids can produce up to 5% from the dry cell mass. Higher yields mean lower costs for production and downstream cleaning. The main problem facing most companies in this space is low yields and their inability to make olivetolic acid, which is a critical compound for making cannabinoids. If you cannot make olivetolic acid, we believe that you will not be able to compete in this market as you will be forced to buy olivetolic acid as an additive, which will significantly increase the cost of production. We believe that this gives us a clear path to be the most cost-effective manufacturer in the field of biosynthetic cannabinoids ”, says CEO Dr. Maxim Mikheev, Ph.D.

Biomedican has filed three additional patents which are a very unique technology to produce the highest quality 99% pharmaceutical cannabinoids, bioorganic, zero toxins and impurities at 70-90% less cost than current prices and 90% less natural resources and energy than growers consume. Biomedican has successfully biosynthesized CBG / CBGA, THCV / THCVA. Current research and development to manufacture CBN / CBNA and THCA will be completed by the end of 2021.

“The patenting of the use of Yarrowia Lipolytica to manufacture cannabinoids gives Biomedican a significant competitive advantage in the biosynthetic cannabinoid market. Not only does Yarrowia Lipolytica produce significantly higher yields than other technologies, but it behaves similarly to the cannabis plant, meaning Biomedican’s technology is very applicable and scalable to produce any cannabinoid with a viable market. We expect to register additional patents to further expand our technological lead and look forward to further approvals of pending patents. The biosynthesis market is one of the fastest growing markets in the world, projected to reach $ 25 billion by 2025, and Biomedican is positioned to lead the field, ”said President Dennis O’Neill.

Cannabinoids are naturally occurring compounds found in the cannabis sativa plant. The two most famous cannabinoids are CBD and THC, which currently make up the largest share of the industry. In addition, scientists have already discovered hundreds of cannabinoids. Few of them have an intoxicating effect; In contrast, most cannabinoids offer various health benefits. As its popularity grows and clinical trials begin, new potential uses are constantly being discovered.

However, many cannabinoids are difficult to isolate from the cannabis sativa plant due to their rarity. Specialists have called them rare cannabinoids, and many of them offer unique properties, uses, and benefits. Research into these rare compounds has led to endless possibilities for consumer and medical applications.

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