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Cal Poly HotHouse company Alydia Health sold for $240 million

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How InPress started working on the Jada system, which prevents abnormal, potentially fatal bleeding in women after childbirth.  The company that became Alydia Health was recently sold for $ 240 million.

How InPress started working on the Jada system, which prevents abnormal, potentially fatal bleeding in women after childbirth. The company that became Alydia Health was recently sold for $ 240 million.

Courtesy photo

A company that started out as a student project by Cal Poly sold the largest amount ever paid to a company born from the University’s Center for Innovation and Entrepreneurship (CIE) HotHouse Accelerator program.

Originally called InPress Technologies and now Alydia Health, the company was sold to Merck spin-off Organon this month for $ 240 million.

Cal Poly students and a team of biomedical entrepreneurs from San Luis Obispo developed the company’s innovative device called the Jada System. The technology helps stop potentially fatal abnormal bleeding in women after giving birth.

The Jada System uses a gentle vacuum to stimulate the contraction of the uterus, which helps stop the heavy bleeding.

Postpartum bleeding can kill mothers in minutes if not treated properly, according to one of the company’s first co-founders, Nathan Bair.

“Alydia received the highest purchase price ever made by any Cal Poly CIE affiliate,” said Judy Mahan, CIE director of economic development.

Jessie-and-team.jpg Nathan Bair (left), Jessie Becker (red shirt in the middle) and Amelia Degenkolb (far right) were part of the early team of Jada designers and entrepreneurs. Courtesy photo

How the business idea began

The idea for the Jada system was cultivated through the CIE’s HotHouse Incubator program with plans for use in the US and developing countries.

CIE and its HotHouse program provide mentoring to support startups, including guidance on securing investor funding and bringing products to market.

The idea for the Jada – which uses a 41 centimeter long intrauterine device made mostly of silicone – was launched in 2011 as a senior project by biomedical students Davis Carlin and Alex Norred of Cal Poly.

Carlin and Norred have applied for Innovation Quest, an innovation competition on the Cal Poly campus. You were also part of the first HotHouse cohort.

Jessie Becker Alexander, a former business administration major from Cal Poly and coordinator of the HotHouse Accelerator program, was also involved with Bair in early founding the company.

Davis and Norred have since moved to other jobs, as have Becker Alexander and Bair. And others took over the management of the company in the course of development.

“We were a rowdy startup for a long time,” says Becker Alexander. “We raised money locally around SLO from consultants and some local investors as well as angel investors in the Bay Area. … And as of 2013, it was ahead of the game, working really hard to bring the technology to the women who need it. “

The company has been affiliated with the nonprofit medical technology organization Fogarty Institute for Innovation in Mountain View, which has also contributed to its success, said Becker Alexander.

The business eventually moved from SLO to Menlo Park.

The sale began in March and made official in mid-June, Bair said.

“Organon’s global infrastructure and resources have been key to our confidence that they are the right strategic partner,” said Rob Binney, Alydia chief executive officer. “From the moment we worked with them, we have all embraced our founders’ original vision of positively impacting the outcomes of childbirth in low- and middle-income countries. The work between our two organizations has already started to achieve this goal. “

Biz Buzz.jpg Nathan Bair and Jessie Becker were among the founders of InPress Technologies, a startup that started at SLO HotHouse and Cal Polys Center for Innovation and Entrepreneurship which became Alydia Health. This photo was taken in 2014. David Middlecamp dmiddlecamp@thetribunenews.com

A humanitarian mission

Each of the early partners, along with other investors, has something in the company and has benefited from as shareholders, but the drive behind the mission has never been forgotten, Bair said.

“As soon as we took investor money, we knew it was going to be a for-profit company, but we have been driven more than anything by this humanitarian mission all along, and we haven’t lost sight of it,” said Bair.

Bair said a core mission is to reduce the number of deaths and make the product available to those in need, which the new owner will continue to do in developing countries.

“We founded the company with a mission and vision to bring the technology to the women who need it most and who are most affected by maternal mortality and morbidity from postpartum bleeding,” said Becker Alexander.

Early on at Cal Poly, Carlin and Norred partnered with Path, a Seattle-based not-for-profit global health organization.

“The concept for this device was one of several suggestions for Path as part of our design team process, and Path eventually asked us to take a different route,” Carlin said in an October 2020 Cal Poly news article. that the idea still has a lot of potential, so we decided to pursue it separately with the permission of Path. “

Other medical methods to stop the bleeding involve applying pressure through intrauterine balloons that inflate.

But the Alydia device offers a safe alternative that draws blood and stimulates contractions, Bair said.

Financing key to success

In the early days, Bair said he used some of the earnings from another medical startup to keep the company afloat along with smaller investments.

Mahan, a lawyer with business expertise, helped them review documents and legal records. On the medical side, there were other experts and entrepreneurs.

“There were a lot of difficulties from 2014 to 2017-2018, and I can remember a lot of great highs and lows,” said Bair. “We had help from great people.”

One of her key biomedical scientists, Amy Degenkolb, worked at Café Ascendo and had expertise in the field. They recruited Degenkolb as a volunteer and she later became a key paid member of the team.

Bair added, “We got tiny chunks of money the whole time. We didn’t have the big investment that startups often do. … Institutional investors didn’t care about women’s health. It was really a real challenge to find these investors. ”

But eventually their product started taking off.

“We found a lot of people who thought what we were doing was really important and exciting and wanted to get involved,” said Bair. “And these people brought us increasingly large amounts of money. … It was a lot of work for us and especially for Jessie to raise all the money until we finally hit the bigger ones (investment finance amounts) in 2016 or 2017. ”

When asked if they were wealthy and what they would do next, Bair said, “It was obviously financially beneficial. One of the things that leave us with is the freedom to take more risks if we want to. We want to work on things that don’t matter how much money you make. “

Becker Alexander, who is now Entrepreneur in Residence at the Carlsen Center for Innovation & Entrepreneurship at Sacramento State University, added: “I am very proud that our team has really persevered and got so far that the technology can actually be delivered and help people. It’s really, really amazing. “

Similar stories from San Luis Obispo Tribune

Nick Wilson reports on the city of San Luis Obispo and has been a reporter for The Tribune in San Luis Obispo since 2004. He also writes regularly on K-12 Training, Cal Poly, Morro Bay, and Los Osos. He is a graduate of UC Santa Barbara and UC Berkeley and is originally from Ojai.

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Women’s Health

Contraception in SA: What you need to know

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Although the majority of South African women of childbearing age use contraception, research shows that access to information about contraceptive methods of their choice is still limited – especially for women in rural communities. This restricted access to information has resulted in an alarming increase in young women looking for emergency options like the morning-after pill.

Health-e News takes a look at the current situation and explores the opportunities for young women.

#AskLwanda

Without much access to information, women turn to social media in hopes of finding answers to their many questions about contraception.

A pharmacist and health advisor from the Eastern Cape, Lwanda, Mkhatshane, used his experience as a retail pharmacist to set up a service where everyone can access health and health information online in real time. The hashtag #AskLwanda was featured on social media platforms such as Facebook, Twitter, Instagram. For those who are not in the mood for social media, calls via Skype and messages via Whatsapp are available.

Its website states: “This pre-existing technology enables you to speak to the customer, confidentially and privately, with the pharmacist. The pharmacist is ready to speak to you and provide information on acute or chronic treatments, drug side effects, contraindications and other information. This convenient service costs only R20 per consultation.

Mkhatshane, known as “pharmacist on call,” said it was shocking how many women are looking for the pill and stressed the importance of people choosing contraception as a choice rather than an emergency option.

He shared some of the most common questions people ask him:

  • Is there any other way to have safe sex without using a condom mara?
  • Is the morning-after pill a contraceptive method?
  • How does the contraceptive ring work?
  • Why is Implanon so expensive?

Here is the thread on contraception.

I focused on the brand 🇿🇦, the price and for whom the method.

1. Enter-use device (IUD)
2. Implant
3rd injection
4. Skin patches
5. vaginal ring
6. Pills

There is no silver bullet. ❌
The choice depends on the patient. pic.twitter.com/DPzG3frVRg

– Online recipes (@AskLwanda) September 5, 2021

Access to SA and contraception

The prevalence rate of contraceptives among all South African women of childbearing age (15–49 years) using modern contraception is 64.6%, according to a study published by BMC in 2019.

Although this percentage is relatively high, it overshadows the problem of quality contraception services, equal access and the ability of women to correctly and consistently use contraceptive methods of their choice. This is especially true for young black women who live in working-class communities and rural areas, according to the study.

The aim of the study was to understand the needs and behaviors of women of childbearing age in South Africa in relation to family planning and contraception. This was achieved through research into women’s biomedical knowledge of the reproductive system and contraception, including the physical and sensory experiences of contraception and how they influence contraception decision-making.

Body mapping explained

In order to examine the physical and sensory experiences of women with contraception methods, body mapping and group discussions were carried out on 57 women of childbearing age during the study.

Body mapping, which can be defined as “the process of creating body maps using drawing, painting, or other art-based techniques to visually represent aspects of people’s lives, their bodies and the world in which they live” – stressed the need to address communication and knowledge gaps related to the female reproductive system.

An example of body mapping and a contraception timeline. (Photo: Reproductive Health Journal)

AYFS – youth and youth-friendly offers

The South African government has developed and implemented various programs through the National Ministry of Health over the years, such as the National Adolescent Friendly Clinic Initiative or NAFCI (2000-2005), the Youth Friendly Services (2006-2011) and the current revised model for youth and youth friendly services (2013-2017).

While there have been remarkable positive results in reducing the prevalence of HIV among young people, this age group continues to face numerous health problems stemming from the lack of widespread systemic change; Lack of in-depth analysis of AYFS programming and implementation; and poor use of health services by adolescents and young people.

As a result, in April 2017, the government and the Ministry of Health, in collaboration with UNICEF and UNFPA, commissioned a Rapid Assessment of Youth and Youth Friendly Services (AYFS) in all nine provinces of the country, with peer educators in some provinces of primary health care facilities in clinics to help young people.

Another BMC research study found the following: The institutions had the essential components for general service delivery, but there were no youth-specific service offers. AYFS is a government priority, but additional facility support is required to meet agreed standards. The fulfillment of these standards could make an important contribution to safeguarding the health of adolescents, in particular to the prevention of unwanted pregnancies and HIV as well as to the improvement of psychosocial management. “

Communication and knowledge gaps

The study concluded that there is an urgent need to address the gaps in communication and knowledge related to female reproductive anatomy, different methods of contraception, and how contraceptives work to prevent pregnancy, thanks to the influence of wider social networks and local language is underlined.

“Overall, women have limited biomedical knowledge of female reproductive anatomy, conception, fertility, and how contraceptives work, which appeared to be exacerbated by a lack of contraceptive advice and support from health care providers. Body map images put existing local perceptions and reproductive health knowledge in the foreground. Most women were where the baby was developing, outside of the womb, in the abdomen, and often relied on the local vernacular when naming the reproductive organs with words like “mouse” and “cake” for the vagina, “so the BMC research.

“Women, including younger women, have identified gaps in their own knowledge of sexual and reproductive health and identified these gaps as important factors that have influenced the acceptance and effective use of contraception. These gaps in knowledge were mainly due to poor or lack of communication and advice from the health services. “

Types of contraception available in SA

There are six different hormonal contraceptive methods available to women in South Africa. All of these forms of contraception are available free of charge in public hospitals, but shortages remain a problem.

Health-e News reported on the contraceptive shortage that hit parts of South Africa, particularly Limpopo, in July. The ongoing COVID-19 pandemic devastated pharmacies and clinics in particular, which were unable to meet the demand for the Depo-Provera contraceptive injection.

Contraception methods available in South Africa:

  • Oral contraceptives
  • Spirals
  • Implants
  • Injections
  • Patch
  • Rings

Oral contraceptives

The pill is a tablet that you take once a day – there are different types of pill. The combined pill contains estrogen and progestin, which prevent the ovaries from releasing eggs. It also thickens the cervical mucus, which prevents the sperm from getting to the egg. The so-called minipill contains only 1 hormone, a progestogen that offers an alternative to those affected by the hormone estrogen.

You should swallow the pill at the same time each day whether you are having sex or not. Ask your doctor whether the combination pill is an appropriate method of contraception for you based on your medical history, and if so, which one is best for you.

Popular options are Yazmin, Levora, Camila, and Jolivette.

Spirals

An intrauterine device, commonly known as an IUD, is a sling device that releases progestin to prevent fertilization for five years. It can be obtained with a prescription and inserted into the uterus by a doctor to help prevent pregnancy. It is an option for women who have never been pregnant and offers immediate protection.

Any hormonal contraception carries a risk of side effects – albeit rare. With IUDs, side effects can include vaginitis (inflammation, discharge), headache, back pain, mood swings, and depression.

Implants and injections

The contraceptive implant is a small rod-shaped plastic object that is placed under the skin on the upper arm. It is available free of charge, accessible in public clinics, and lasts for three years. Mkhatshane said it should be implanted during the first five days of menstruation and it works immediately. Enlarged breasts, weight gain, and an irregular period are some of the side effects that can occur.

Depo-Provera and Nuristerate injections are available in both private and public health settings. Depo affects glucose intolerance and can be associated with grimacing. While Nuristerate is considered the milder of the two injectable contraceptives available. Depo-Provera slowly diffuses over a period of three months after injection. It offers instant protection when injected within the first week of menstruation and can be used by all women, including those with epilepsy and those unable to take estrogen. It can prevent pregnancy for nine to 18 months after a single injection. The side effects are similar to those of the implant.

Mkhatshane noted that women with the nuristerate injection would still get their periods but would not experience spotting or prolonged bleeding. This is the preferred injection for women with diabetes, but Mkhatshane warned that women with hyperpigmentation (chloasma) should avoid the injection as it could make their condition worse.

Patches and Rings

The skin patch releases hormones through the skin and into the blood and works to prevent ovulation, thicken vaginal fluid to prevent sperm survival, and alter the lining of the uterus to make it harder for a fertilized egg to attach. Mkhatshane suggested that women with a history of active breast cancer, liver disease, and diabetes with high blood pressure should avoid this method.

The vaginal ring is a small plastic ring that is inserted into the vagina. It releases a steady dose of hormones into the bloodstream to prevent pregnancy. According to Mkhatshane, the vaginal ring is just as effective as contraceptive pills but should not be used by women who smoke and are older than 35 years. Side effects include nausea, vaginal discharge, and decreased sexual appetite.

What do SA women prefer?

Injectable birth control was by far the most common method, used by 25% of women, according to a 2017 study by the South African Medical Journal (SAMJ). Other methods were less common and only a negligible proportion used an IUD (1.6%), while 8.6% used a birth control pill. – Health-e news

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Women’s Health

Coming second in the game of life – Kate Pickett

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“We don’t want to behead the big poppies,” said Boris Johnson in July. But for Kate Pickett, his “leveling” ambitions will require a flattening of the entire social divide.

The not entirely social winners? – a wedding reception on the Thames (Ian Luck / shutterstock.com)

There was enough athletic competition in the summer to remind us how hard it can be not to be quite the winner. In England there was great excitement when the national soccer team reached the final of the European Championship, only to lose there on penalties to Italy. There was almost immediately a backlash of racism and hatred towards the players who missed those crucial final shots on goal.

At the US Open tennis tournament, the women’s final was played by two talented teenagers who had both done spectacularly to get this far – but the disappointment of runner-up Leylah Fernandez was hard to see. And at the Tokyo Olympics, one competitor after another said to the cameras, ‘I’m not here for second place; I’m not here for silver. ‘

But in life, unlike in sport, is the second one surely good enough? We can’t all be winners, but if we have a good education, a good job, and all of our material needs, is that enough for our health and wellbeing?

In some ways it is true: nobody needs excessive income or wealth to be healthy, and too large an income gap between rich and poor is detrimental to the health of the population and the good functioning of society. But it is also true that, like in sports, being the winner is not that important.

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Social slopes

Almost all major causes of death and illness show social inequalities. They are not only more common among the poor and the lower classes of society, while they are rare among the rest of the population. Instead, there is a steady gradient in the incidence of various diseases and causes of death between each level of the social ladder. So while morbidity and mortality are certainly highest among the worst-off, if you are not entirely at the top of the income bracket, not entirely in the top social class, or not well educated, there is a risk of poor health. Illness and death are still a little higher than those directly above you.

This is an almost ubiquitous pattern around the world. We see it in life expectancy and infant mortality, in health behaviors like smoking and obesity, chronic diseases, heart attacks, infections, and most cancers. There are one or two exceptions, particularly breast and prostate cancer, but otherwise there are social health gaps everywhere.

In the graph below, the bars show life expectancy for men and women in England, with the population divided into ten groups, from those most deprived on the left to those least deprived on the right. When we look at such charts, we usually notice the differences between the top and the bottom – here a life expectancy of 9.5 years between the most deprived and least deprived men and 7.7 years between the most deprived and least deprived Men least disadvantaged women.

Life expectancy at birth by decile and gender, England 2018

social gradient

But with every step from prosperity to misery, from right to left, both men and women, on average, lose a little bit of life expectancy. Men in the least disadvantaged group live an average of about 82 years, about a year and a half less than men in the least disadvantaged group of all. Women in the second best group live just over 85 years, but women in the top group live about a year longer.

These are surprising penalties for being among the least disadvantaged instead of making it into the top 10 percent. No one in the top 20 percent is denied any material necessity, and no one is likely to lack the knowledge to make healthy decisions. Nevertheless, people in the second decile still die younger and suffer from almost all acute or chronic diseases more often than in the first.

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Status matters

What these social gradients tell us is how important the social environment is – it’s status itself that matters. If you have a little less status than the one at the top, you are not doing as well as if you are the highest status. If we are to address health inequalities, we need to level the entire gap, not just try to tackle health problems from the bottom up.

While social gradients are almost ubiquitous in the health sector, the steepness of the gradient varies from place to place. Societies with lower economic inequalities have a widespread tendency to have smaller absolute differences in health. Reducing inequalities in income, wealth, education and social class will help society as a whole – not just the poorest or those in dire need. We would all be winners if the playing field was leveled.

Covid-19 of course also has a social gradient. It was never an “equality disease,” as some claimed early on. It’s too late for the pandemic we are in, but some serious social and economic leveling would help us cope with whatever might come next.

This is a joint publication by Social Europe and IPS-Journal

social gradient

Kate Pickett is Professor of Epidemiology, Associate Director of the Center for Future Health, and Associate Director of the Leverhulme Center for Anthropocene Biodiversity, all at the University of York. She is co-author with Richard Wilkinson on The Spirit Level (2009) and The Inner Level (2018).

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Women’s Health

Mon Health Stonewall Jackson Memorial Hospital physician honored by WVSOM

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WESTON, W.Va. – Mon Health Stonewall Jackson Memorial Hospital Obstetrician / Gynecologist Robert Harris, MD, was born on Friday 17th), in Lewisburg.

The Outstanding Preceptor Awards are given to physicians who show professionalism and demonstrate their service to students, including a commitment to teaching, mentoring, and the educational process. They also serve as positive role models, reflecting their commitment to the osteopathic teachings or the Hippocratic Oath and commitment to patient care. Preceptors support and advise the medical students of the WVSOM in their clinical rotations in the third and fourth years.

Students in each region nominate and vote on the preceptors for the awards. The Central East region encompasses the central portion of WV, including Elkins, Buckhannon, Weston, Bridgeport, and Morgantown.

Dr. Harris earned his bachelor’s degree from Quinnipiac College, Connecticut, before earning his medical degree from St. Georges University in the West Indies. He completed his residency at Staten Island University Hospital in New York. He is certified by the American Board of Obstetrics and Gynecology and a Fellow of the American Congress of Obstetricians and Gynecologists.

“DR. Harris is an excellent teacher. He challenges you as a student to see your potential. He allows us to perform procedures and has very hands-on experience in obstetrics / gynecology. I’m in with little interest in obstetrics / gynecology gone the rotation but after working with Dr. Harris I appreciate the field a lot more, ”wrote one student.

Other nominators wrote: “Dr. Harris goes way beyond that for his students. He’s a great teacher and really helps students prepare for the post-test rotation and boards. ”Others wrote that Dr. Harris was one of the finest teachers they had worked with and that his ability to teach and work with patients was “paramount”.

In an interview a few years ago, Dr. Harris carefully considered why he made women’s health his specialty.

“I chose Women’s Health because I enjoy short-term and long-term care options. For example, an emergency room cannot maintain a long-term relationship with the patient. This field gives me the opportunity to have both surgical and medical treatments, ”he explained. “But perhaps one of the most important aspects of my practice is the opportunity to be present at the birth. Having a baby is a unique and extraordinary experience. It is more moving than any other experience in the medical field. “

Other doctors at Mon Health Stonewall Jackson Memoria Hospital who have received the award in the past include Dr. Robert Snuffer and Dr. Brian Hornsby.

Approximately 50 hospitals, clinics, and medical centers across West Virginia participate in WVSOM’s statewide campus program. Outstanding Primary Care and Specialty Preceptor Awards were given to physicians in each campus region, including the central (split), eastern, northern, southern, central, southeastern, and southwestern regions.

To learn more about Mon Health Obstetrics and Gynecology, visit MonHealth.com/OBGYN or call 304-269-3108 in Weston.

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