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cbdMD Therapeutics Releases Research Plan

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CHARLOTTE, NC – (BUSINESS WIRE) – cbdMD, Inc. (NYSE American: YCBD, YCBDpA), one of the leading, most trusted and recognized CBD companies, today announced that its recently established division, cbdMD Therapeutics, has entered into talks with one of the leading US cannabinoid companies -Research institutes to identify novel cannabinoids for therapeutic use. The company also expects to identify uses for nutritional supplements through this process. The company expects to finalize the agreement with the research institute and begin studies in the fall of 2021. The intended purpose of these studies is to provide data that will feed into the cbdMD Therapeutics research pipeline. Upon completion of this work, cbdMD Therapeutics will conduct the necessary toxicology studies with Ion Tox, a leading in vitro toxicology and ADME-PK testing company, to support the safety of the cannabinoids of interest. These safety data will support the following preclinical human studies to investigate the effectiveness of the cannabinoids. This work will support potential future applications for Investigational New Drugs (INDs) at the FDA’s Center for Drug Evaluation and Research (CDER) in humans and animals.

“CbdMD began its first research phase in autumn 2020 with its first in vivo animal study and clinical studies. The second phase of research is now underway to identify promising cannabinoids for drug therapies in humans and pets. As an added benefit of our comprehensive therapeutic research plan, we believe that our research will also enable our cbdMD, Paw CBD, and cbdMD Botanicals brands to make certain statements about our consumer products, such as activity, maintaining focus and positive mood, and improving health Mobility. The ability to make science-based claims in the field of nutritional supplements will continue to improve the reputation and marketability of our brands, especially as we now anticipate the full integration and wide adoption of CBD in currently unavailable distribution channels including Food Drug and Mass (FDM) . , Third party marketplaces like Amazon and international marketplaces worldwide. In addition to these new distribution channels, we anticipate opportunities to market, advertise and sponsor CBD products on all major TV networks, sports leagues and e-commerce platforms for CBD companies that have proven clinical data to support their products. The investments we are making today not only raise the cbdMD brands but also raise the bar for the entire CBD industry, ”said Martin Sumichrast, Chairman & Co-CEO of cbdMD, Inc.

“The potential opportunity to discover how cannabinoids can provide significant health and medicinal benefits for humans and animals is incredible. cbdMD intends to work with leading research institutes, global drug development companies and like-minded brands to unlock the potential benefits of cannabinoids, ”said Dr. Sibyl Swift, VP, Scientific & Regulatory Affairs.

About cbdMD, Inc.

cbdMD, Inc. is one of the leading, most trusted and recognized cannabidiol (CBD) brands with an extensive line of US-made, THC-free1 CBD products. Our cbdMD brand currently includes over 130 SKUs of high quality premium CBD products, including CBD tinctures, CBD gums, CBD topicals, CBD capsules, CBD bath bombs, CBD bath salts, CBD sleeping pills and CBD drink mixes. Our Paw CBD branded pet products include over 45 SKUs of veterinarily formulated products including tinctures, chewy candies, topical products in various strengths, and our CBD Botanicals brand of beauty and skin care products includes 15 SKUs including facial oil and serum, toners, moisturizers, clear skin, face masks, scrubs and body care. To learn more about cbdMD and their full line of US-grown, THC-free1 CBD oil products, please visit www.cbdmd.com, follow cbdMD on Instagram and Facebook, or visit any of the 6,000 retail stores selling CBD- Lead products.

1 THC-free is defined as being below the detection limit using validated scientific analysis methods.

Forward-Looking Statements

This press release contains certain forward-looking statements that are based on current expectations and involve certain risks and uncertainties within the meaning of the US Private Securities Litigation Reform Act of 1995. Such forward-looking statements can be made clear by the use of words such as: ” should ” ” may ” ” intend ” ” anticipate ” ” believe ” ” estimate ” ” projects’ ” ‘projections’ ” ‘expects, plans, plans and proposes. These forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and other factors, some of which are beyond our control and difficult to predict, and could cause actual results to differ materially from those expressed or projected in the forward-looking statements may vary, including but not limited to results from research studies. You are urged to carefully review and consider all warnings and other disclosures, including those filed under the heading “Risk Factors” in cbdMD, Inc.’s Annual Report on Form 10-K for the fiscal year ended September 30, 2020 with the Securities and Exchange Commission (the “SEC”) on December 22, 2020, Item 1A. Risk factors included in our Quarterly Report on Form 10-Q for the period ended March 31, 2021, as filed with the SEC on May 12, 2021, and our other filings with the SEC. All forward-looking statements involve significant risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements, many of which are generally beyond the control of cbdMD, Inc. and difficult to predict. cbdMD, Inc. assumes no obligation to update forward-looking statements unless required by law. The information that appears on our websites and social media platforms, including but not limited to Instagram and Facebook, is not part of this press release.

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Pressure BioSciences Nanoemulsion Platform Will Bring More Effective, More Shelf-Stable CBD-Infused Beverages to the Market by End of 2021

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Image provided by Pixabay

CBD-infused beverages will soon be available to consumers worldwide thanks to the nanoemulsion-producing Ultra Shear Technology ™ (UST ™) platform developed by Print BioSciences, Inc (OTCQB: PBIO). With a projected average annual growth rate (CAGR) of 21.2% over the next 7 years, the CBD market is projected to become 13 billion stable, water-soluble versions of the CBD oil by 2028 to allow for more predictable dosing and degradation during the Reduce distribution and storage. That is exactly what the new UST platform from Pressure BioSciences (PBI) did. How it works and what it means for consumers.

Why consumers need a water-soluble version of CBD

CBD is an oil-soluble compound found in cannabis plants. When extracted from the plant, it has no psychoactive side effects, but still offers many of the mental and physical health benefits that cannabis is known for.

Researchers have found that CBD has the potential to manage anxiety, reduce stress, and even reduce the severity of psychotic symptoms in schizophrenic patients. It also shows potential as a powerful anti-inflammatory agent, making it possible to relieve muscle and joint pain, treat symptoms of rheumatoid arthritis, and prevent or slow the growth of cancer cells.

Most importantly, all of these potential benefits come with few or no adverse side effects, which sets CBD-based treatments apart from many of the existing standards of care for these conditions, which are often associated with unpleasant or even harmful side effects.

However, the incredible potential of CBD-based treatments and wellness products has yet to be fully realized. While vegetable oil versions of CBD are already on the market, these oil-based products are not well absorbed by the human body, making it difficult for consumers to take full advantage of the compound.

The World Health Organization estimates that only 6% of CBD oil is actually absorbed when ingested or applied topically. The rest goes through the body, unused and wasted. As a result, the dosage is difficult to predict and the potential health benefits of the cannabis derivative are reduced by the inability of the body to fully absorb the oil.

The story goes on

PBI’s UST platform is helping CBD oil reach its potential

While the search for a method to reliably and consistently convert CBD oil into a water-soluble product that is more easily absorbed has continued, researchers have had little luck so far. Dr. Christopher Hudalla, President and Chief Scientific Officer (CSO) at ProVerde Labs, which tests cannabis-derived materials, commented on the lack of availability of cannabis-based products that are both truly water-soluble and shelf-stable for long enough to be marketable.

ProVerde’s CSO stated, “The introduction of a new technology platform that can consistently produce the ultra-small droplet size nanoemulsions necessary for reliable shelf life of over 1 year, including resistance to freeze-thaw challenges, will be a be a critical turning point and an explosive growth opportunity in the CBD and cannabis product industries. “

This new technology is PBI’s UST platform, which uniquely combines extremely high pressures with intense shear forces to break down CBD oil into droplets so small that the human body can effectively absorb the medicinal compound contained in the oil at significantly higher rates .

In addition, the nano-sized droplets are small enough to withstand regrowth into larger droplets – a problem that leads to this separation and deposition that you see in other emulsions like salad dressings or nut butters. Even with repeated freezing and thawing, a tried and tested test to determine long-term stability, the nanoemulsions made with UST do not separate from PBI or do not decompose.

PBI’s innovative technology makes it possible to ship CBD-enriched beverages worldwide and store them for longer periods of time without fear of the product losing its potency and effectiveness. As a result, consumers will have access to more effective and precisely dosed CBD beverages than ever before. PBI is partnering with industry leaders in the food and beverage space to bring the groundbreaking new CBD infusions to market before the end of 2021.

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© 2021 Benzinga.com. Benzinga does not offer investment advice. All rights reserved.

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Study Suggests Hemp Extract Is An Effective Weight-Loss Aid

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A proprietary hemp extract shows promise as a supplement for promoting weight loss, according to a study funded by a grant from the National Institutes of Health. Data from the double-blind, placebo-controlled study showed that all 100 participants who took Nitro-V hemp extract daily lost weight and lost up to 22 pounds over 90 days. The minimum weight loss for those taking the supplement was 5 pounds, while 64% of participants in the placebo group either gained weight or saw no change.

The study participants who took the hemp extract, which is high in cannabidiol (CBD), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), and other cannabinoids, also showed improvements in other metabolic health metrics and important wellness indicators without changing their diet and exercise habits to change. Participants who took Nitro-V saw their body mass index (BMI) decrease an average of three points and lost an average of 2.4 inches from their waist measurements. On average, the study participants in the placebo group gained weight and saw that their BMI remained the same.

Cannabis (hemp) extract.

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Almost 75% of Americans are overweight

According to data from the CDC, more than 73% of adults 20 years or older in the United States are overweight or obese. The health risks associated with obesity can be serious and include heart disease, diabetes, and high blood pressure. Additional CDC data shows that between 2013 and 2016, more than 49% of American adults reported trying to lose weight in the past 12 months.

“Those working to lose weight and improve their overall health are looking for every benefit they can find to help them stick to their exercise and nutrition plans,” said Arthur Jaffee, CEO of Nitro-V manufacturer ECS Brands , in a press release. “Given the results of these studies, we believe that Nitro-V could be the tool to help many achieve their weight loss potential and feel better.”

To conduct the clinical study, which had not yet been published in a peer-reviewed journal, the researchers assembled a group of 125 subjects to participate in the research. A total of 100 participants received either one or two 50 mg servings of Nitro-V daily, the remaining 25 participants received a placebo. Study participants were not told that they were participating in a weight loss study and that they had not changed their diet or exercise habits.

At the beginning and end of the 90-day study period, participants visited the Mayo Clinic campus in Scottsdale, Arizona and completed standardized surveys on health determinants such as diet, appetite, anxiety, and pain. The researchers also monitored the subjects’ weight, BMI, waist circumference, and vital signs, and performed full blood tests to measure blood sugar, cholesterol, and organ health, as well as other diagnostic tests. A statistician analyzed the data collected during the study to identify trends and evaluate the importance of the results. The research was funded by a small business owned by the National Institutes of Health and conducted by a contract researcher with 20 years of experience in product safety studies.

Each softgel microcapsule serving of Nitro-V contains 50 mg of hemp extract with a combination of cannabinoids such as CBD, THCV and CBDV in an organic hemp seed oil base. The solvent-free hemp extract contains the full cannabinoid profile of the source plant, including less than 0.1% THC. Further processing increases the THCV and CBDV levels in the supplement.

The “thin cannabinoid”

Cannabinoids from cannabis, including hemp, act on the body’s endocannabinoid system, which helps maintain physiological, cognitive, and emotional stability. Research has shown that THCV can act as an effective appetite suppressant, which has earned it the nickname “thin cannabinoid”. Other studies have shown that THCV can also help regulate blood sugar levels. THCV also has anti-inflammatory and antispasmodic properties.

Nitro-V hemp extract softgels from ECS Brands.

Photo courtesy of ECS Brands

Jaffee notes that recent research has shown that CBD and THCV can affect lipid and glucose metabolism in animals, both important factors in maintaining a healthy weight. The study also found that CBD had several positive effects on hyperglycemia, largely due to its anti-inflammatory and antioxidant properties. Further evidence from animal studies shows that CBD modulates the cardiovascular response to stress, which plays a role in weight gain and loss. However, the link between CBDV and weight loss is “less direct,” he says.

“Research shows that CBDV is a powerful anti-inflammatory agent that can play a role in both appetite and weight,” Jaffee wrote in an email. “Reduced inflammation in the body helps optimize the performance of the metabolic organs, and fat cells themselves are metabolic organs. Inflamed fat cells do not work properly and can contribute to unhealthy weight gain. “

The Nitro-V study also showed several other changes in the health and well-being of the participants, including many with the potential to affect weight loss. Participants who used the supplement in the study showed a 61% reduction in hunger and had fewer food cravings. In addition, all 37 study participants who took Nitro-V and were classified as prediabetic had their blood sugar levels returned to normal by the end of the 90-day study. The subjects also reported less difficulty resisting food cravings and showed improvements in sleep, happiness, and anxiety. Research also showed that the hemp extract was well tolerated and safe, with blood tests showing that all safety and toxicity levels remained within healthy, normal ranges.

A hemp field in rural Belgium.

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While the study was designed to examine the effects of Nitro-V on weight loss, Jaffee says the data suggests the supplement may have other health and health benefits as well.

“The ultimate goal of the study was to identify the overarching power of the ECS system, and the results indicate effects beyond weight loss and appetite suppression,” he writes. “But as with all cannabinoid and ECS researchers today, we still have many unanswered questions about how interactions between cannabinoids and the ECS lead to health improvements.”

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Could CBD Oil Help with Nausea?

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When it comes to the CBD industry, misinformation is rampant. There are too many brands out there trying to make quick money in a phenomenally fast growing market. With a lot of money at stake, these companies are less concerned about what they can do for their customers and more concerned about their profit margins.

The benefits of CBD are known due to the relentless research of dedicated scientists. However, the actions of certain brands lead the general public to remain skeptical.

My advice is to avoid brands that claim that their CBD oil “treats” everything. Unless the cannabinoid is approved by the FDA for medical treatment, no brand is allowed to make any medical claims. However, there is no question that CBD is a potential life changer for many people, for example against nausea. Let’s find out more.

What is nausea?

It is usually classified as a stomach discomfort that makes you want to throw up. It affects a wide variety of people and can have a variety of causes. Common reasons for nausea are:

  • heartburn
  • GERD
  • An infection or a virus
  • Motion sickness
  • Extreme pain
  • Medication

It’s important to remember that nausea is not a disease in itself. Instead, it’s your body’s response to one of a number of conditions. Although it feels awful, nausea is often necessary for your body to fight off unwanted invaders.

Although there are several anti-nausea drugs on the market, there is evidence that CBD may be effective against nausea.

How could CBD help with nausea?

THC is the most common intoxicating cannabinoid found in marijuana. It’s also available in small quantities in hemp. THC is known to create a high, and it binds to endocannabinoid receptors in the brain and spinal cord.

CBD works on these receptors too, but in a different way. First of all, it doesn’t bind directly to the CB1 and CB2 receptors. This helps explain why it doesn’t induce an intoxicating high. CBD helps the body produce higher levels of endocannabinoids like anandamide.

What does the research say?

Currently, much of the research on CBD for nausea is based on people with cancer. Nausea and vomiting are common side effects of chemotherapy. A study published in 2016 examined how cannabinoids can regulate acute and anticipatory nausea. The researchers found that a combination of THC and CBD could provide some relief to cancer patients undergoing chemotherapy.

The American Cancer Society actually puts cannabinoids on its list of drugs to use to treat nausea and vomiting. It suggests that these compounds may be useful in cases where traditional anti-nausea medications are ineffective.

A 2011 review of animal studies also looked at how cannabinoids can regulate nausea and vomiting. The researchers found that CBD was potentially useful against nausea due to its interaction with serotonin receptors. Serotonin is a hormone that affects our mood, behavior, and wellbeing.

THC is potentially more effective at reducing the effects of nausea. However, it causes a high intoxication and is not legal in over a dozen US states. It’s also not legal in many countries around the world. Although CBD is not strictly legal in America, it is widely used and tolerated. It is also widely used around the world, with many nations specifically saying that it is legal.

What types of CBD should I use for nausea?

You will likely get more benefits from CBD for nausea by trying a full-spectrum product. This is because research suggests that the presence of THC might increase its anti-nausea effects. A full-spectrum CBD product contains dozens of compounds and terpenes. However, in the United States, it cannot contain more than 0.3% THC. In the UK, the maximum THC content is 0.2%.

When you feel sick, it makes sense to avoid anything that could make you feel like you are vomiting. While some people can tolerate edibles or oils, others cannot. CBD capsules are another option. They have no taste and are easy to swallow. You could try vaping CBD for a faster effect, but your stomach may not like it!

It also makes sense to start with a relatively low dose and work your way up. Start with 5-10 mg of CBD and increase it as needed.

Final thoughts on CBD for nausea

According to the research available, there is plenty of evidence that CBD could be effective against nausea. While most of the studies are on cancer patients recovering from chemotherapy, you may find that CBD works for your nausea. There are also many other potential benefits of CBD that are worth exploring.

When trying out CBD for nausea, you need to carefully consider your method of consumption. Buy a moderate amount first to see how you react. If you can handle it, you can buy more and possibly increase the amount you consume.

Image by unbekanntuserpanama from Pixabay

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