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Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8

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THC-O-acetate is even stronger than regular THC. Here’s what you need to know to try it safely.

From Delta-8 to Delta-10, cannabinoids made from hemp have a moment. And now there’s a new kid on the block that’s about to be taken over: THC-O. But while the Deltas are gentler versions of the classic THC or Delta-9 of cannabis fame, THC-O can be three times more potent than its mainstream cousin.

Because it is made from hemp, THC-O has a different legal status than cannabis products, especially in many states that do not yet have a recreational market. That being said, there is still some debate over whether THC-O is “synthetic THC” under federal law, which is still a controlled substance and illegal, even if it’s made from hemp. So proceed with caution.

We are still learning a lot about THC-O, although there is research on it that dates back to the 1940s. As its popularity grows, it’s important to keep up with the facts – and how to find safe, effective, and reputable products.

Related

Meet THC-O, a hemp-derived compound that is three times stronger than THC

Here’s what we know about THC-O, and how to make sure it’s from a trusted source before trying it out.

THC-OCourtesy of five ™

What is THC-O and where does it come from?

The full name of THC-O is THC-O-acetate, and the earliest research we have on it dates back to American military experiments involving non-lethal incapacitated agents in the 1940s. Researchers tested the compound on dogs. At the end of the experiment, the dogs had clearly lost control of their motor skills.

In order to obtain THC-O from hemp, CBD is first converted into Delta-8 or a similar THC modification. But it goes one step further. Adding acetic anhydride to the mixture turns it into an acetate – especially THC-O.

But don’t try this at home! Acetic anhydride is highly corrosive and flammable and is dangerous to your health, safety and the environment unless it is manufactured in a strictly controlled laboratory environment. This is one of several reasons why you should only buy THC-O if you know it is from a reputable source.

How do you take THC-O?

When it’s done, THC-O-acetate is a kind of thick brown liquid. You can take it in a vape cartridge, tincture, or edible. It takes about 20-30 minutes for it to set in.

THC-OCourtesy of five ™

How does THC-O feel? How is it different from Delta-8, -9 and -10?

Delta-8 and Delta-10 are both milder and generally less intoxicating than regular Delta-9 THC. Delta-8 is known for its more sedative effects, while Delta-10 has a reputation for being a more active, sativa-like high.

THC-O is significantly stronger than not only Delta-8 and -10, but also normal THC. Some users have reported a more spiritual high with powerful effects that can even border on hallucinogenic effects. As with any drug, the effects and tolerability vary from person to person.

How to Buy THC-O Safely

Because THC-O is largely unregulated, buying THC-O from a mysterious source carries many risks. Cannabis researcher James Stephens told Leafly that sometimes producers don’t even know or claim they don’t know what’s in their own product: “I ask, ‘What’s the rest?” And they say,’ We don’t know. ‘ .. That’s what usually ends the conversation. “

There’s also the possibility that THC-O-Oil contains toxic additives – and we’ve already seen sketchy additives cause serious health problems. Since it’s so much stronger than other forms of THC, you’ll want accurate potency most of all.

You want to buy from a company that is completely transparent, with clear laboratory results and a high level of responsibility towards its customers. five has been making trustworthy, transparent, full-spectrum products that combine CBD with other beneficial hemp compounds for years, and they were one of the first companies to offer products with Delta-9 and Delta-10. They know how to make perfect blends of cannabinoids – and they have experience making them safely, with the consumer’s experience in mind. They even offer certificates of analysis from third party laboratories so you know what it says on the bottle matches the contents of the product.

THC-OCourtesy of five ™

five has worked hard to develop THC-O products that meet their high standards. Right now, you can get to know them through their fan favorite offers – and if THC-O appeals to you, you know you have a producer you can trust for a great experience.

At the moment five has a special offer for Leafly readers. Click the link below to try a full size product for free. You only pay for shipping and five covers the rest.

Daily buzz gummies: Five’s flagship gummies are both delicious and powerful, with a full range of beneficial botanicals and 5 mg of Delta-9 THC per gummy bear. Like all of their gummies, they’re vegan too. * Availability is subject to local laws.

Sleeping rubbers: Five’s Recovery Gums add the natural sleep aid melatonin to their perfect blend of hemp cannabinoids – with up to six times more cannabinoids than other brands.

THC + CBD liquid capsules: Get all of the benefits of full-spectrum hemp in one easy-to-use capsule with CBD, THC, CBN, and CBC.

Full spectrum THC + CBD chocolate: For a more luxurious edible experience, five offers their signature blend of cannabinoids in two chocolate flavors: milk chocolate and dark sea salt chocolate.

Full spectrum THC + CBD oil: It all started with this oil. Two flavors of tinctures, citrus and mint chocolate, are packed full of CBD, THC, CBN, CBC, and terpenes.

THC-OCourtesy of five ™

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CBD for Vertigo: Research and Side Effects

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It can be unsettling to experience dizziness, a feeling that the world is spinning around you. Severe dizziness can even affect your ability to complete everyday tasks as it upsets your balance. Something as harmless as standing up too quickly can make you dizzy due to a rapid drop in blood pressure.

However, dizziness is not a requirement. Instead, it’s a symptom. It can occur due to underlying conditions like multiple sclerosis or problems with the inner ear. Certain medications can also make you feel dizzy.

Treatment for dizziness depends on the cause. You might be interested in home remedies or even natural substances like cannabidiol (CBD).

In this article, we take a closer look at CBD, whether it can help with dizziness and possible side effects. We will also review dizziness treatments and report on when to see a doctor for dizziness.

CBD comes from the cannabis plant. It has several potential health benefits, including insomnia and pain relief.

CBD is similar to another cannabinoid called tetrahydrocannabinol (THC), but it doesn’t produce the same “high” THC.

You can find CBD in many forms, including:

People looking for a full body effect to relieve conditions like chronic pain and insomnia should stick to ingested products like oils, gums, and capsules. Topicals are a better option for targeted pain such as joint pain.

There are also several types of CBD:

  • Isolate. This is pure CBD and contains only CBD.
  • Broad spectrum. Broad-spectrum CBD contains some cannabis compounds (like other cannabinoids) but no THC.
  • The whole spectrum. Full-spectrum CBD contains some THC (less than 0.3 percent for federally legal products) and countless other cannabis plant compounds such as terpenes, flavonoids, and other cannabinoids.

Research suggests that CBD works better when combined with THC, which is why a full-spectrum product is more beneficial than an isolate. This is known as the entourage effect.

However, if you want to avoid THC, you would be better off with an isolate or broad spectrum product. Note, however, that any type of CBD can contain traces of THC, which can be detected in a drug test.

CBD is unlikely to help with dizziness. However, it can help with related symptoms like nausea.

Animal studies from 2016 showed that CBD reduced nausea in rats, while human studies in people undergoing chemotherapy showed that a combination of CBD and THC can help with treatment-related nausea.

Still, the available research on CBD and nausea focuses primarily on chemotherapy-related nausea rather than vertigo-related nausea.

If you are dizzy, it is possible that CBD will make you feel dizzy. Some research on cannabis (including THC and CBD) suggests dizziness as a side effect.

Another 2020 study of people undergoing chemotherapy found that although THC and CBD worked together to reduce nausea and vomiting, 31 percent of participants experienced moderate or severe dizziness, disorientation, or sedation.

There is also research that CBD can lower blood pressure, which could potentially make dizziness worse.

A 2017 study found that participants who took 600 mg of CBD had lower blood pressure than the placebo group. However, the study was very small with only nine male participants.

The World Health Organization believes it is safe to take CBD. But it is possible to experience mild side effects like:

  • Appetite changes
  • Weight changes
  • fatigue
  • diarrhea

Despite the short list of side effects, it is important to speak to your doctor if you are on any medication and consider taking CBD. It is possible for CBD to interact with certain drugs, such as those with a grapefruit warning on them.

While the Food and Drug Administration (FDA) sends warning letters to CBD brands that misrepresent or mislabel their products, the organization does not regulate CBD products in the same way as prescription drugs.

This means that not all CBD products are safe to consume as they may not contain what the label says.

A 2021 study that looked at poison control center cases between 2019 and 2020 found that reports of products containing CBD were on the rise. Reported side effects from these cases are dizziness, dizziness, and nausea. Researchers suggested that this surge could have something to do with inaccurate or fraudulent labeling of CBD products.

For this reason, when choosing CBD, it is important to contact a company that has products tested by a reputable third-party laboratory and provides up-to-date Certificates of Analysis (COAs).

Treatment for dizziness typically depends on the underlying medical condition that is causing the dizziness. For example, if medication is causing your dizziness, your doctor may recommend a different one.

Treatment also depends on the type of vertigo you have.

  • Peripheral vertigo. Peripheral vertigo is caused by a problem with your inner ear that is responsible for your balance.
  • Central vertigo. Central vertigo affects your brain.

Depending on the type and cause, your doctor may recommend the following:

  • Drugs for acute dizziness
  • Exercise or physical therapy to improve balance (for people with permanent inner ear diseases)
  • Avoid dizziness triggers
  • surgical treatment (only as a last resort)

In people with benign positional vertigo, twisting the head (like the Epley Maneuver) can help reposition calcium deposits that can cause problems in the inner ear.

It’s time to see a doctor for dizziness if:

  • does not go away
  • happens frequently
  • happens with other symptoms, such as:
    • Loss of consciousness
    • Vision problems
    • fever
    • Tingling or weakness in your body
    • slurred speech
    • Trouble walking
    • Chest pain

There is no evidence that CBD can help with dizziness. In fact, it can make dizziness worse in some people.

If you have frequent attacks of dizziness, you should speak to your doctor. It can be a sign of an underlying condition that needs treatment.

Is CBD Legal? Hemp-derived CBD products (containing less than 0.3 percent THC) are legal at the federal level, but are still illegal under some state laws. CBD products derived from marijuana are illegal at the federal level, but legal under some state laws. Find out about the laws of your state and wherever you travel. Keep in mind that over-the-counter CBD products are not FDA approved and may be inaccurately labeled.

Steph Coelho is a freelance writer with chronic migraines with a particular interest in health and wellness. If she’s not clicking on her keyboard, she’s probably stuck in a good book.

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Lung Cancer Shrinks in Patient Using CBD Oil

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One case report describes the dramatic shrinkage of a tumor to a quarter of its original size in a non-small cell lung cancer (NSCLC) patient who refused conventional treatment, continued smoking, and later revealed that she was taking cannabidiol (CBD.) Oil.

The patient was an 80 year old woman.

At diagnosis, the tumor measured 41 mm and there was no evidence of local or further spread. Therefore, it was suitable for a standard treatment regimen consisting of surgery, chemotherapy, and radiation therapy, the authors note.

The patient refused conventional treatment. She was monitored every 3-6 months with regular CT scans.

After 2.5 years, the CT scans showed that the tumor had shrunk to 10 mm.

The patient then announced that she had taken CBD oil, which was suggested by a family member. It was taken orally about two to three times a day.

Details of the case were published in BMJ Case Reports on October 14th.

“We are aware of the limitations of this case report,” write the authors, directed by Kah Ling Liew, MD, of Watford General Hospital, Watford, UK.

“Although there appears to be a link between ‘CBD oil’ ingestion and the observed tumor regression, we cannot conclusively confirm that tumor regression was due to the patient’s ingestion of ‘CBD oil’,” they comment.

The team also notes that there are similar case reports in the medical literature.

Both points were highlighted by experts who responded to the publication via the UK Science Media Center.

“This is one of many promising individual case reports of medical cannabis self-treatment in various cancers,” said David Nutt, DM, FRCP, FRCPsych, Edmond J. Safra Chair in Neuropsychopharmacology, Imperial College London, London, United Kingdom. “Such case reports are biologically credible given the adaptogenic nature of the endocannabinoid system.”

He noted that “a case report alone is not enough to prove that one caused the other – we need studies for that. There are already some controlled studies out there and more are needed to understand the potential of medicinal cannabis in a number of cancers. “

Another expert, Edzard Ernst, MD, PhD, Professor Emeritus of Complementary Medicine, University of Exeter, Exeter, UK, pointed out that cannabinoids have reduced the size of prostate cancer tumors in animal models. “Previous case reports have shown encouraging results in human cancers as well,” he noted. He also said that more studies are needed.

“Case reports cannot be considered reliable evidence, and there is currently no data from rigorous clinical studies to suggest that cannabis products alter the natural course of cancer,” Ernst said.

Patient declined recommended treatment

The patient initially presented with a persistent cough that did not heal with antibiotic therapy. She has a history of mild chronic obstructive pulmonary disease, osteoarthritis, and high blood pressure. She is a current smoker with a 68 year history of smoking. She has no history of alcohol consumption and is taking several prescription drugs.

After an initial CT examination, she was given a CT-guided lung biopsy and diagnosed with NSCLC (TNM stage T2bN0Mx). Further analysis of the tumor tissue showed that it was negative for ALK and EGFR mutations. PDL1 was expressed by <1% of the tumor cells. No distant metastases were found.

A subsequent CT scan showed that the main tumor in the right median lobe had shrunk from 41 mm to 33 mm. There were new bilateral nodules in the upper lobe, one in the left apex measuring 4 mm and one in the right apex measuring 6 mm.

The patient was referred to a cardiothoracic surgeon for a possible lobectomy, but the surgeon refused to undergo surgery. She was then referred to the oncologists. She underwent repeated CT and positron emission tomography (PET) scans, which showed that her cancer had further shrunk. The CT showed a reduction of 11 mm and the PET a reduction of 18 mm. The left apical knot had resolved and the right superior lobe knot was reduced in size.

The patient was offered stereotactic ablative radiation therapy, which she refused. Since she had refused all standard therapies, it was decided to “watch and wait”. The patient was subjected to regular CT monitoring.

The tumor continued to regress over the course of 2.5 years. By February 2021, it had shrunk to 10mm, an overall reduction of 76% of the maximum axial diameter. The average reduction rate during the observation period was 2.4% per month.

“This case was brought to the attention of the local pulmonary MDT [multidisciplinary team] in February 2019 when serial imaging showed a reduction in tumor size despite not receiving conventional treatment for her lung cancer, “the authors write.

The patient was contacted to discuss her results. She announced that she was using CBD oil and had started taking it in August 2018. No changes were made to her prescription medication, diet, or lifestyle, and she continued to smoke a pack of cigarettes each week.

“I wasn’t very interested in traditional cancer treatments,” said the patient, “because I was concerned about the risks of surgery and I saw my late husband suffer from the side effects of radiation therapy. My relative suggested that I try cannabidiol should (CBD) oil “to treat my cancer, and I’ve been taking it regularly ever since. I am overjoyed that my cancer is shrinking, which I think was caused by the “CBD oil”. I can take it very well and I intend to do this treatment indefinitely. “

The source of the CBD oil was outside of the UK. According to their supplier, the main active ingredients were Δ9-tetrahydrocannabinol (THC) with 19.5%, CBD with 20.05% and tetrahydrocannabinolic acid with 23.8%.

“The product this patient was using was reported to be high in THC (the intoxicating component of cannabis) and from outside the UK,” commented Tom Freeman, PhD, Senior Lecturer and Director, Addiction and Mental Health Group, University of Bath. Bath, UK. “This type of product is very different from most CBD oils, which contain mostly CBD. Unlike prescription drugs, CBD wellness products lack guarantees of quality, safety, or effectiveness and should not be used for medicinal purposes. “

The authors have not disclosed any relevant financial relationships. Nutt chairs the scientific committee of the Drug Science charity, which receives unrestricted educational grants from some medical cannabis companies. Ernst and Freeman have not disclosed any relevant financial relationships.

BMJ Case Rep. 2021; 14: e244195. Full text

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CBD Oil Side Effects: Full Breakdown and Best Products

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This article contains affiliate links to products. We may receive a commission on purchases made through these links.

There are many reasons why CBD products have become so popular. One of the main driving factors behind the success of this ingredient is the many therapeutic benefits it offers. CBD, which is extracted from hemp, interacts with the endocannabinoid system (ECS). This system promotes homeostasis while playing a role in many functions and processes, including sleep, appetite, mood, and energy.

Read on to learn more about the many positive side effects CBD oil can offer.

Provides natural pain management

Going through life with everyday pain is not easy. Chronic pain sufferers often have to choose between less than ideal treatment options, including prescription drugs, which are at high risk of addiction and addiction.

Studies have shown that CBD oil can act as an all-natural oil Painkiller, even for those who have chronic pain caused by underlying health conditions such as arthritis and fibromyalgia. When ingested, CBD affects the activity of the endocannabinoid receptor, which reduces inflammation.

Since inflammation is often the cause of most pain, many people experience relief from using CBD oil.

Reduces depression and anxiety

Depression and anxiety are two of the most common mental illnesses that people of all ages are diagnosed with. These conditions are often life changing and have devastating effects on health and overall wellbeing.

In fact, according to the World Health Organization, depression is that Main cause of disability, worldwide, with anxiety being the sixth leading cause. These conditions are usually treated with prescription drugs, which come with a whole list of side effects. Some even carry the risk of substance abuse and addiction.

CBD oil has shown promise as a potential treatment for anxiety and depression. Studies have shown that CBD can have antidepressant effects. CBD is believed to interact with the receptors in the brain that control serotonin levels. This is the neurotransmitter that regulates mood, happiness, and anxiety.

Improves sleep

CBD is known to induce a sense of calm and relaxation. While CBD won’t make you drowsy, the compound works in the body to create a balance. As you become less stressed and worried, you will automatically find that falling asleep and staying asleep at night is much easier.

CBD also helps with some of the most common causes of insomnia, such as pain or racing thoughts. This will give you the sleep you need to start the day rested and focused.

Reduces acne

Acne is one of the most common skin conditions affecting almost 10% of the world’s population. There is no single cause for the condition, although it has been linked to various factors including bacteria, overproduction of sebum, underlying inflammation, and genetics.

Scientific studies have shown that CBD can benefit acne sufferers because of the compound’s ability to reduce many of the underlying causes of acne.

Research has shown that CBD may prevent activation of inflammatory cytokines that cause breakouts. It also prevents the sebum glands from secreting excess sebum.

Other advantages

This list only scratches the surface of the many benefits CBD can offer. Research has also uncovered many other positive side effects, including:

Do you think CBD is worth trying? Whether you’re looking for a better night’s sleep or natural relief from the pain that weighs you down every day, high quality CBD oil can help. Here are five of the best CBD oil products that you might want to try.

The 5 best CBD oils

1. Verma farms cbd

Verma Farms is perhaps best known for their CBD infused gums, but their CBD oils are just as delicious. These oils are made with the highest quality unadulterated broad spectrum CBD extract along with hemp oil, MCT oil, terpenes and natural flavoring.

The best thing about the Verma Farms CBD oil collection is the amazing flavors that make for a sweet, tropical experience. Every drop is sure to please your pallet! Who could say no to a product that not only tastes good, but also offers many advantages?

Some of the most popular flavors of Verma Farms CBD oil include:

  • strawberry

  • pineapple

  • mango

There are other options too, including Mint, Lemon Lime, and Natural.

2. penguin

Penguin is another top name in the industry that has a tasty collection of CBD oil. Penguin CBD products are made with pure, high quality ingredients that support your wellbeing. Penguin believes everyone deserves a quiet, relaxed life and is developing products that offer just that.

Each bottle is made with broad spectrum extract sourced from the best hemp grown in Oregon. Penguin CBD oil is also made with other high quality ingredients including hemp oil, MCT oil, natural flavor, and terpenes.

Penguin CBD oil is available in a variety of delicious flavors including Citrus, Mint, Strawberry, and Cookies & Cream. There is also natural (unflavored) oil available if you prefer a non-flavored product.

3rd Even CBD

Evn CBD oil is designed to help keep people balanced and on an even keel. When the mind and body are in harmony, it is much easier to live happier and calmer lives. Evn CBD offers a wide variety of products including high quality CBD oils.

Each bottle is made with broad spectrum CBD oil, MCT oil, and stevia extract to add a touch of sweetness. Evn CBD oils contain 0 THC, are vegan, GMO-free and gluten-free. They are also tested in the laboratory for effectiveness, safety, and effectiveness.

CBD oils are available in two flavors, natural and mint. The mint flavor is definitely the most popular and offers a refreshing, calming experience.

4th Corn bread hemp

Cornbread Hemp is one of the first CBD brands to receive a USDA-certified organic seal. This means that all of the ingredients in the branded CBD oil are organic and natural so you can buy and use this product with complete confidence.

The unique thing about Cornbread Hemp is that it is made with hemp extract from whole plants. Each bottle contains a mix of terpenes and cannabinoids, including CBD, CBG, CBN, CBC, and THC. But don’t let the existence of THC put you off! The amount is below the 0.3% legal threshold so you won’t get high on this product.

Cornbread Hemp offers whole flower and distilled CBD oils. Full bloom has a highly relaxing effect, which makes it best for evening use. The distilled oil contains less THC and other cannabinoids, making it safe to take at any time of the day.

5. Lazarus Naturals

Lazarus Naturals CBD oil is all natural, gluten-free and vegan. Each bottle is made with organic ingredients like MCT oil, natural flavors, and CBD extract. The brand sells CBD oils fortified with various extracts, including CBD isolate and full-spectrum CBD.

Lazarus Naturals offers some of the most unique CBD oil flavors including:

  • Yuzu

  • French vanilla mocha

  • Strawberry hibiscus

  • Blood orange

  • Winter mint

  • Chocolate mint

Whether you’re looking for a fruit-flavored oil or you’re looking for something to fill your sweet tooth, Lazarus Naturals has the product for you.

Final thoughts

CBD oil is one of the best ways to get your daily dose of CBD. When consumed sublingually, CBD oil provides quick and long-lasting relief. Whether you’re looking for pain relief, better sleep, or less stress and anxiety, CBD oil can offer these benefits along with many others.

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